1.6.5 (2021-10-26)
  o skip some tests on CRAN that may fail randomly
1.6.4 (2021-09-01)
  o Fix vignettes to avoid CRAN warnings on systems without pandoc or webshot2
  o Make sure NAs in bootConfint are handled
1.6.3 (2021-06-29)
  o Fix code for compatibility with new ggplot2 version
1.6.2 (2021-03-10)
  o Fix issue with testing when variance at off-axis points equals zero
1.6.0 (2020-12-16)
  o Residual resampling according to mean-variance trend
  o Use bootstrapped confidence intervals for point-by-point and overall effect sizes
  o Internal redesign for speed-up, using "d1d2" identifiers
1.5.3 (2020-09-10)
  o fix issue with `generalizedLoewe` and `hsa` functions when data is a tibble
1.5.2 (2020-07-24)
  o fix issue with smooth monotherapy plot when dotted line was not shown due to numeric inaccuracies
1.5.1 (2020-07-02)
  o show smooth prediction curve on the marginal fit plot
  o show warning for agonist/antagonist combination when using generalized Loewe model
1.4.3 (2020-01-30)
  o fixes for special case of 2 flat monotherapy profiles
1.4.2 (2020-01-17)
  o even better support for flat monotherapies, consistent calls/colors for all representations (contour plot, summary table and 3d plot)
  o added clarification to description of Bliss method in the "Methodology" vignette
  o fixed typos
1.4.1 (2019-06-20)
  o improve tests
1.4.0 (2019-06-18)
  o added Alternative Loewe independence null model
1.3.0 (2019-02-28)
  o added Bliss independence null model
1.2.3 (2018-11-21)
  o better support for flat monotherapies
1.2.2 (2018-09-07)
  o make sure if no replicates are there model/unequal method is not allowed
1.2.1 (2018-08-24)
  o fix regression bug to allow custom axis labels for the contour plot
1.2.0 (2018-06-13)
  o support heterogeneous variance with new argument 'method' for 'fitSurface'
1.1.3 (2018-05-14)
  o show EC50 in log10 terms for monotherapy summary
  o allow custom compound names for plotting
1.1.2 (2018-05-07)
  o fix monotherapy formula in the vignette
1.1.1 (2018-01-02)
  o added reference to the original article
  o fix DESCRIPTION file according to new R CMD check policy
1.1.0 (2017-09-22)
  o isobologram() plot is now available for ResponseSurface objects
    It is also now included in the shiny app.
  o summary.ResponseSurface does not fail if marginal fits have constraints
  o Change of package maintainer
1.0.3 (2017-08-18)
  o Contour plot for maxR now has correct p-value labels
  o Summary for marginal fits does not fail if Hessian computation failed
1.0.2 (2017-07-31)
  o extra arguments in fitMarginals are now passed to the optimizer functions
1.0.1 (2017-06-29)
  o `predict` method added for the MarginalFit objects
1.0 (2017-06-28)
  o Initial public release
