phase1PRMD: Personalized Repeated Measurement Design for Phase I Clinical
Trials
Implements Bayesian phase I repeated measurement design that
accounts for multidimensional toxicity endpoints and longitudinal efficacy
measure from multiple treatment cycles. The package provides flags to
fit a variety of model-based phase I design, including 1 stage models with
or without individualized dose modification, 3-stage models with or without
individualized dose modification, etc. Functions are provided to recommend
dosage selection based on the data collected in the available patient cohorts
and to simulate trial characteristics given design parameters.
Yin, Jun, et al. (2017) <doi:10.1002/sim.7134>.
| Version: |
1.0.2 |
| Depends: |
R (≥ 3.0.0), coda (≥ 0.13), ggplot2, stats |
| Imports: |
rjags, arrayhelpers, MASS, reshape2, plyr, dplyr, RColorBrewer, gridExtra, kableExtra, knitr |
| Published: |
2020-03-09 |
| DOI: |
10.32614/CRAN.package.phase1PRMD |
| Author: |
Lu Zhang, Jun Yin |
| Maintainer: |
Lu Zhang <luzhangstat at gmail.com> |
| License: |
GPL-2 | GPL-3 [expanded from: GPL (≥ 2)] |
| NeedsCompilation: |
no |
| SystemRequirements: |
JAGS (http://mcmc-jags.sourceforge.net) |
| Materials: |
README, NEWS |
| CRAN checks: |
phase1PRMD results |
Documentation:
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